ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
Association between Benign Paroxysmal Positional Vertigo and Osteoporosis, Vitamin D Deficiency: A Case Controlled Study
1 Clinic of Otorhinolaryngology, Haseki Training and Research Hospital, İstanbul, Turkey  
2 Clinic of Otorhinolaryngology, Derince Training and Research Hospital, Kocaeli, Turkey  
3 Department of Otorhinolaryngology, Yeni Yüzyıl University School of Medicine, İstanbul, Turkey  
J Int Adv Otol ; : -
DOI: 10.5152/iao.2016.2640
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Key Words: Vitamin D, osteoporosis, positional vertigo

Objectives: Benign Paroxysmal Positional Vertigo (BPPV) is a common type of vertigo caused by the peripheral vestibular system. The majority of  cases are accepted as idiopathic. Calcium metabolism also plays a primary role in the synthesis/absorption of otoconia made of calcium carbonate, and so might be an etiological factor in the onset of BPPV. In our study we aimed to investigate the role of osteoporosis and vitamin D  in the etiology of BPPV by comparing BPPV patients to hospital-based controls.


Methods: This is a case-control study comparing prevalance of osteoporosis and vitamin D deficiency in 78 BPPV patients and 78 hospital-based controls. The mean T-scores and serum vitamin D levels were compared.  The risk factors of osteoporosis, physical activity, diabetes mellitus, body mass index and blood pressure were all compared in between groups. In order to avoid selection bias groups were also stratified as subgroups according to age, gender, and menopausal status.


Results: In our study, the rates of osteoporosis and vitamin D deficiency detected in BPPV patients were reasonably high. But there was no significant difference in mean T-scores and vitamin D levels, osteoporosis, and vitamin D deficiency prevalence between the BPPV group and controls.


Conclusion: The prevalence of osteoporosis and vitamin D deficiency is reasonably high in the general population. Unlike the general tendencies in the literature, our study suggests that osteoporosis and vitamin D deficiency are not risk factors for BPPV; the coexistence of BPPV with osteoporosis and vitamin D deficiency is incidental. 

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