ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes
1 Department of Otorhinolaryngology, Yüzüncü Yıl University School of Medicine, Van, Turkey  
2 Department of Otorhinolaryngology, İstanbul Taksim Training and Research Hospital, İstanbul, Turkey  
3 Department of Chemistry, Yüzüncü Yıl University Faculty of Science, Van, Turkey  
4 Department of Anesthesiology and Reanimation, Van Training and Research Hospital, Van, Turkey  
5 Yüzüncü Yıl University Vocational School of Health Services, Van, Turkey  
6 Yüzüncü Yıl University School of Health, Van, Turkey  
J Int Adv Otol 2017; 13: 345-348
DOI: 10.5152/iao.2017.3617
Key Words: Chronic otitis media, trace elements, heavy metals

OBJECTIVE: To determine the serum iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), magnesium (Mg), cobalt (Co), and lead (Pb) levels in patients with chronic otitis media (COM) and to evaluate the association of the serum levels of these elements with treatment outcomes.


MATERIALS and METHODS: Thirty-one healthy volunteers and 31 patients with COM were prospectively included in this study. Serum levels of Fe, Zn, Mn, Mg, Cu, Co, and Pb were determined by an atomic absorption UNICAM-929 spectrophotometer.


RESULTS: Serum Co, Pb, and Fe levels were significantly increased (p<0.001) and serum Cu, Zn, Mg, and Mn levels were significantly reduced in patients with COM compared with controls (p<0.001). Serum Co and Mn levels were significantly decreased (p<0.001 and p<0.005, respectively) and serum Cu levels were significantly increased after surgery (p<0.005). The other evaluated blood chemicals and heavy metals did not exhibit significant differences (p>0.05).



CONCLUSION: Significant alterations in the serum chemical composition of patients with COM were observed. Moreover, with surgical treatment, serum levels of some of these chemicals were significantly altered. Further prospective studies are warranted to elucidate the exact association of these alterations in the etiopathogenesis of COM.



Cite this article as: Bozan N, Dinç ME, Demir H, Yalınkılıç A, Gönüllü E, Turan M, et al. Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and their Association with Surgical Treatment Outcomes. J Int Adv Otol 2017; 13: 345-8.

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