ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population
1 Department of Otorhinolaryngology, Kaohsiung Medical University School of Medicine,,Health Management Center, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan  
2 Department of Internal Medicine, Kaohsiung Medical University School of Medicine.,Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan  
3 Clinic of Otorhinolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan  
4 Department of Otorhinolaryngology, Kaohsiung Medical University School of Medicine;Clinic of Otorhinolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan  
5 Health Management Center, Kaohsiung Municipal Hsiao-Kang Hospital,.Department of Internal Medicine, Kaohsiung Medical University School of Medicine, Kaohsiung, Taiwan  
6 Department of Otorhinolaryngology, Kaohsiung Medical University School of Medicine, Clinic of Otorhinolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan  
J Int Adv Otol ; : -
DOI: 10.5152/iao.2018.5109
Key Words: Age-related hearing impairment, metabotropic glutamate receptor, GRM7, single nucleotide polymorphism, Asian
Abstract

OBJECTIVES: Age-related hearing impairment (ARHI) is a major disability among the elderly. This study aimed to analyze the association of single nucleotide polymorphisms (SNPs) of metabotropic glutamate receptor 7 (GRM7) gene with ARHI in an elderly population in Taiwan.


MATERIALS and METHODS
: This was a community-based study performed in a metropolitan hospital. Participants ≥65 years of age were recruited. Participants with a pure tone average (PTA) of speech frequencies in the better ear of >35 decibel hearing level (dBHL) were classified into the case group, whereas those with PTA ≤25 dBHL were classified into the control group. The association of SNPs rs11928865, rs1353828, rs9814809, and rs9880404 with ARHI was analyzed.


RESULTS
: In 106 cases and 190 controls, alleles of all SNPs were found not to be associated with ARHI. The genotype of rs9880404 was found to be associated with ARHI in a dominant pattern, but the genotypes of rs11928865, rs1353828, and rs9814809 were found not to be associated with ARHI.


CONCLUSION
: GRM7 SNPs are associated with susceptibility to ARHI, but the significance of this finding in a Taiwanese population differed from that observed in European studies. Further studies may help to determine Taiwanese (Asian)-specific SNPs associated with ARHI.

 

Cite this article as: Chang NC, Dai CY, Lin WY, Yang HL, Wang HM, Chien CY, et al. The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population. J Int Adv Otol 2018; DOI: 10.5152/iao.2018.5109

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AVES | Copyright © 2018 The European Academy of Otology and Neurotology | Latest Update: 19.04.2018