ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
Evaluation of Serum Endocan Levels in Sensorineural Hearing Loss
1 Department of Otorhinolaryngology and Head and Neck Surgery, Namik Kemal University School of Medicine, Tekirdağ, Turkey  
2 Department of Biochemistry, Namik Kemal University School of Medicine, Tekirdağ, Turkey  
3 Department of Biostatistics, Namik Kemal University School of Medicine, Tekirdağ, Turkey  
J Int Adv Otol ; : -
DOI: 10.5152/iao.2018.5051
Key Words: Sensorineural hearing loss, endocan, endothelial dysfunction, microvascular dysfunction
Abstract

OBJECTIVES: The aim of this study was to reveal the possible role of endothelial dysfunction in sensorineural hearing loss (SNHL) by determining the serum endocan levels of patients with varying degrees of SNHL.


MATERIALS and METHODS
: Patients with documented SNHL and healthy controls were included in the study, whereas those with a known history of chronic inflammatory condition were excluded. In addition, a recent history of use of glucocorticoids, nonsteroid anti-inflammatory drugs, or any ototoxic medications was also considered as an exclusion criterion due to its potential impact on endocan synthesis and metabolism. Following overnight fasting, blood samples were collected, and serum endocan levels were measured. For statistical analysis of the data, PASW Statistics for Windows version 18 was used.


RESULTS
: The comparison of the subgroups yielded no statistically significant difference between the control and mild-to-moderate SNHL groups. Despite the increase in hearing loss, the difference between the endocan levels in these patients did not increase proportionately and was not statistically significant (p>0.05). The patients in the severe SNHL group had a higher level of serum endocan than those in other groups, and the difference was statistically significant (p<0.05).


CONCLUSION
: The serum endocan levels failed to show a proportionate increase with increasing degree of SNHL, indicating that there is no precise association between SNHL and serum endocan levels. The serum endocan levels of patients with SNHL did not significantly differ from those of the healthy controls.


Cite this article as
: Gültekin E, Ersözlü T, Demirel OB, Kaymaz Ö, Topçu B, Çiftçi Z. Evaluation of Serum Endocan Levels in Sensorineural Hearing Loss. J Int Adv Otol 2018; DOI: 10.5152/iao.2018.5051.

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AVES | Copyright © 2018 The European Academy of Otology and Neurotology | Latest Update: 16.08.2018