The Journal of International
Advanced Otology
Original Articles

Modulated Alpha Power as a Predictor of Tinnitus Alleviation

1.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University, Seoul, Korea

2.

Audiology Institute, Hallym University of Graduate Studies, Seoul, Korea

3.

Sensory Organ Research Institute, Medical Research Center, Seoul National University Seoul, Korea

4.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea

J Int Adv Otol 2024; 20: 397-404
DOI: 10.5152/iao.2024.231051
Read: 545 Downloads: 207 Published: 26 September 2024

Background: Pain associated with subjective tinnitus is known to be alleviated by treatments using a repetitive transcranial magnetic stimulation (rTMS). However, the mechanisms underneath are still on debate. We investigated the mechanism of tinnitus alleviation using time–frequency analyses.

Methods: Twenty-four patients were randomly assigned to the dual-site stimulation group (temporal and frontal stimulation, TF), singlesite stimulation group (temporal stimulation, T), or sham stimulation group. An age-matched control group was also included (n = 12). Electroencephalography (EEG) was recorded and patient data were analyzed before and after treatment.

Results: A frontal increase in EEG power was observed in the alpha (8-12 Hz) frequency band domain after treatment; this increase was most pronounced in the TF group, followed by the T group. The TF and T groups showed increased alpha power in the fronto-central channels only in the silent period between paired-pulse tones. The TF and T groups showed decreases in alpha power in the temporal region, particularly in the neural response to the first of the paired-pulse tones. The difference in tinnitus handicap index between pre- and post-treatment was positively correlated with the alpha power of the silent period in the frontal and fronto-central channels.

Conclusion: Dual-site stimulation showed the greatest alleviation of tinnitus-related discomfort, followed by single-site stimulation. Additionally, the modulation of alpha power was prominent in the active stimulation groups. Low frequency rTMS can alleviate tinnitus by increasing alpha band power and reducing hyperactivity.

Cite this article as: Kyong J, Noh T, Park M, Lee J, Oh S, Suh M. Modulated alpha power as a predictor of tinnitus alleviation. J Int Adv Otol. 2024;20(5):397-404.

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