ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
The Clinical Benefit of Device Therapy for Meniere’s Disease in Adults: Systematic Review and Meta-Analysis
1 Hubei University of Medicine, Taihe Hospital, Center for Evidence-Based Medicine and Clinical Research, Shiyan, China  
2 Department of Neurology, Hubei University of Medicine, Taihe Hospital, Shiyan, China  
3 Department of Rehabilitation Medicine, Hubei University of Medicine, Taihe Hospital, Shiyan, China  
J Int Adv Otol 2019; 15: 121-129
DOI: 10.5152/iao.2019.5937
Key Words: Meniere’s disease, device therapy, vertigo control, function level, hearing level, inner ear electrophysiology, meta-analysis
Abstract

OBJECTIVES: This study aimed to assess the clinical benefit of device therapy on controlling the symptoms of Meniere’s disease (MD).

 

MATERIALS and METHODS: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Internet, and Wanfang Data before January 13, 2018. We selected randomized controlled clinical trials, case-controlled studies, and cohort studies that dealt with outcomes of device therapy for the treatment of MD.

 

RESULTS: Sixteen trials met our inclusion criteria. The use of device therapy resulted in improved vertigo control, which was described as a reduction in the number of vertigo days by month (weighted mean difference [WMD]: 3.15, 95% confidence interval [CI]: 2.00-4.31), in the number of vertigo episodes by month (WMD: 7.37, 95% CI: 2.40-12.35), and in the vertigo visual analog score (WMD: 41.51, 95% CI: 34.68-48.34). In addition, the overall complete vertigo control (class A) rate was 50% (95% CI: 37%-64%). The device therapy also reduced the number of sick days by month (WMD: 4.56, 95% CI: 2.15-6.97), and the functional level improved (WMD: 2.66, 95% CI: 2.15-3.17). The electrocochleographic parameters decreased. The device therapy proved beneficial for hearing changes (WMD: 3.19, 95% CI: 0.66-5.71). No publication bias was found in the funnel plot and the results of Egger’s test.

 

CONCLUSION: This study showed that the device therapy might reduce vertigo attacks and sick days in patients with MD. Additionally, the function level and hearing level may improve after the device therapy. In addition, the decrease in electrocochleographic parameters showed that inner ear electrophysiology improved after device therapy.

 

Cite this article as: Wang SJ, Yang H, Yao YY, Gu HY, Lin LL, Zhang C, et al. The Clinical Benefit of Device Therapy for Meniere’s Disease in Adults: Systematic Review and Meta-Analysis. J Int Adv Otol 2019; 15(1): 121-9.

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AVES | Copyright © 2019 The European Academy of Otology and Neurotology | Latest Update: 15.08.2019