ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
The Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss
1 Department of Otorhinolaringology, University Medical Centre Ljubljana, Ljubljana, Slovenia  
2 University of Ljubljana Faculty of Medicine, Ljubljana, Slovenia  
J Int Adv Otol 2017; 13: 318-321
DOI: 10.5152/iao.2017.3896
Key Words: Intratympanic, sudden sensorineural hearing loss, high dose dexamethasone, salvage therapy
Abstract

OBJECTIVE: The aim of this study was to assess the efficacy of a single high dose intratympanic (IT) dexamethasone (DEX) as salvage therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) after unsuccessful treatment with oral corticosteroid (CS).

 

MATERIALS and METHODS: This was a prospective open-label study of 59 patients treated with IT DEX after systemic CS therapy has failed. All patients received high dose (24 mg/mL) IT DEX in a single injection through myringotomy.

 

RESULTS: Of the 59 patients, 40.7% showed improvement in their mean pure tone average (PTA) with IT DEX (p=0.005). The difference in the mean PTA after oral CS treatment only from baseline was not statistically significant (p=0.074). The time from onset of hearing loss to the start of therapy was significantly associated with the outcome (p=0.03).

 

CONCLUSION: We determined that high dose IT DEX as salvage therapy was beneficial when the primary treatment with oral CS had failed. An early start of the treatment significantly influenced the improvement of hearing.

 

Cite this article as: Kordiš Š, Battelino S. The Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss. J Int Adv Otol 2017; 13: 318-21

Key Words
Authors
All
Author's Corner
Reviewer's Corner
Survey
AVES | Copyright © 2019 The European Academy of Otology and Neurotology | Latest Update: 15.08.2019