ISSN 1308-7649 | E-ISSN 2148-3817
1 Department of Otorhinolaryngology, Mustafa Kemal University School of Medicine, Hatay, Turkey  
2 Department of Pathology, Mustafa Kemal University School of Medicine, Hatay, Turkey  
3 Department of Microbiology, Mustafa Kemal University School of Medicine, Hatay, Turkey  
4 Department of Pharmacology, Mustafa Kemal University School of Medicine, Hatay, Turkey  
J Int Adv Otol ; : -


OBJECTIVES: The aim of this experimental study was to compare dose-related effects between topical thymoquinone (TQ) and other topical agents used in the management of acute otitis externa (AOE) in a rat model.

: Forty-eight male Wistar albino rats were divided into six groups with eight rats each. Group I was the control group with no external otitis, whereas external otitis was induced in the other five groups (study groups). Dexamethasone, 0.1% TQ, 0.4% TQ, ciprofloxacin, and 0.9% sodium chloride drops were administered once daily to the rats in Groups II–VI, respectively. The treatment was regularly administered for 10 days. Pathological and microbiological evaluations were performed. The thicknesses of the stroma and epithelium in the external auditory canal (EAC) were measured using an occulometer. Edema in the stroma, density of inflammatory cells and blood vessels, presence of fibroblasts, and changes in collagen fibers in EAC were evaluated in five different areas to determine the area of the highest concentration of epithelial thickness, stromal thicknesses, edema, and inflammatory cells and classified into four different grades (0=no change, 1=mild, 2=moderate, and 3=severe).

: In terms of anti-bacterial and anti-inflammatory properties, the higher concentration of TQ (0.4%) was more effective than dexamethasone and 0.1% TQ.

: TQ alone, especially at 0.4%, could be used topically in the treatment of AOE, without any requirement for combined treatment.


Cite this article as
: Demirel H, Arlı C, Özgür T, İnci M, Dokuyucu R. The Role of Topical Thymoquinone in The Treatment of Acute Otitis Externa: An Experimental Study in Rats. J Int Adv Otol 2018. DOI: 10.5152/iao.2018.4213.

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