ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
Histamine Antagonists for Treatment of Peripheral Vertigo: A Meta-Analysis
1 Department of Emergency Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran  
2 Department of Emergency Medicine, Loghmane-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.  
3 Shahid Beheshti University of Medical Sciences School of Medicine, Tehran, Iran  
J Int Adv Otol 2015; 11: 138-142
DOI: 10.5152/iao.2015.1169
Key Words: Drug therapy, histamine antagonists, meta-analysis, randomized trial, vertigo

OBJECTIVE: Vertigo, the hallucination of movement of oneself or one’s surroundings, can have substantial adverse effects on the quality of life of affected patients. It is essential to decrease the frequency, severity, and duration of vertigo attacks using effective medications with minimal debilitating adverse effects. We performed a meta-analysis of available clinical trials to evaluate the efficacy of histamine antagonists in the treatment of vertigo compared to the rate of resolution in untreated control groups.


MATERIALS and METHODS: A systematic search of articles in any language from January 1970 to March 2015 was performed through the following databases: the Cochrane Central Register of Controlled Trials, Medical Literature Analysis and Retrieval System Online, the Excerpta Medica Database, Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature, Allied and Complementary Medicine Database, Web of Science,, and Google. Randomized controlled trials comparing each kind of antihistamine to untreated control participants in the treatment of vertigo (blinded/unblinded) were screened for inclusion. Three reviewers separately performed data extraction from the included trials using a standard data abstraction form. Three other researchers read the final list of all articles retained. Discrepancies were settled by mutual consensus between the authors. Random effects models were applied to estimate the pooled odds ratio (OR) and 95% confidence interval (CI) using the Review Manager software. The evaluation of publication bias was performed by Egger’s test and Begg’s funnel plot.


RESULTS: We identified 13 eligible citations. The pooled OR was 5.370, 95% CI (3.263–8.839), and I2=56.0%, with no obvious evidence of publication bias.


CONCLUSION: Our results provide clarification of the effectiveness of several categories of histamine antagonists compared with placebos in controlling peripheral vertigo.

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